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However, tesofensine faces significant challenges - cardiovascular side effects (increased heart rate and blood pressure) raised safety concerns, FDA has not approved it despite promising efficacy data, development stalled after Phase 3 trials, currently available only through research chemical suppliers with questionable legality, and the stimulant-like mechanism creates dependency and tolerance risks not seen with GLP-1 agonists

Overall, the reduction was modest but meaningful at the population level, amounting to about 7 fewer cases of any substance use disorder (including nicotine) for every 1,000 people treated

When to contact a healthcare provider Most injection site reactions are self-limiting and respond to home treatment

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